Transcriptome-Guided Drug Repositioning

Drug Repositioning in Cancer

The development of new therapeutic agents, in any kind of disease, requires either long time or high costs; indeed 10 15 years of research are required to market a drug, resulting in an overall cost of about 1.8 billion dollars [1]. In addition, drug development in oncology is very challenging due to cancer biological complexity, actually comprising several subtypes of diseases carrying differe...

Orphan/rare drug discovery through drug repositioning

There are many, often life-threatening, rare/orphan diseases for which there are few or no therapeutic options. They individually affect few people, but collectively impose very high social and economic burdens. New approaches are bringing big pharma resources to solving the problem through drug repositioning of approved drugs. Advances are being spurred by public and private partnerships, gove...

Drug combination therapy increases successful drug repositioning.

Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tol...

Systematic drug repositioning through mining

Network mirroring for drug repositioning

BACKGROUND Although drug discoveries can provide meaningful insights and significant enhancements in pharmaceutical field, the longevity and cost that it takes can be extensive where the success rate is low. In order to circumvent the problem, there has been increased interest in 'Drug Repositioning' where one searches for already approved drugs that have high potential of efficacy when applied...